Duration of effect of abobotulinumtoxinA (Dysport®) in adult patients with upper limb spasticity (ULS) post-stroke or traumatic brain injury

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Effects of repeated abobotulinumtoxinA injections in upper limb spasticity

INTRODUCTION The efficacy of single injections of abobotulinumtoxinA (Dysport) is established in adults with upper limb spasticity. In this study we assessed the effects of repeated injections of abobotulinumtoxinA over 1 year. METHODS Patients (n = 258, safety population) received 500 U, 1,000 U, or 1,500 U (1,500-U dose included 500-U shoulder injections) for up to 4 or 5 treatment cycles. ...

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comparing the efficacy of botulinum toxin with tizanidine in upper limb post stroke spasticity.

background: this study evaluated the efficacy of focal intramuscular injection of botulinum (bont) toxin type a in comparison with oral tizanidine (tzd) in treatment of post-stroke upper limb spasticity. methods: this was a double-blinded randomized clinical trial that recruited 68 patients with post-stroke upper limb spasticity. thirty-four patients received bont (dysport(®)) injections in aff...

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Systematic Literature Review of AbobotulinumtoxinA in Clinical Trials for Adult Upper Limb Spasticity

OBJECTIVE The aim of this study was to elucidate clinical trial efficacy, safety, and dosing practices of abobotulinumtoxinA (ABO) treatment in adult patients with upper limb spasticity (ULS). METHODS A systematic literature review was performed to identify randomized controlled trials and other comparative clinical studies of ABO in the treatment of adult ULS published in English between Jan...

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Comparing the efficacy of botulinum toxin with tizanidine in upper limb post stroke spasticity

BACKGROUND This study evaluated the efficacy of focal intramuscular injection of botulinum (BoNT) toxin type A in comparison with oral tizanidine (TZD) in treatment of post-stroke upper limb spasticity. METHODS This was a double-blinded randomized clinical trial that recruited 68 patients with post-stroke upper limb spasticity. Thirty-four patients received BoNT (Dysport(®)) injections in aff...

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ژورنال

عنوان ژورنال: Annals of Physical and Rehabilitation Medicine

سال: 2017

ISSN: 1877-0657

DOI: 10.1016/j.rehab.2017.07.167